Fig 1: Histological evaluation of aberrant Cdk5 activity in human tissue microarray. (A-B) Representative immunohistochemical micrographs showing Cdk5 phosphosites viz. P-RBL1 and P-LARP6 in tissue microarray sections of MTC tumors. magnification; 4x (scale, 200μm), 20x (scale, 50 μm). (C-D) Quantification is presented as the optical density for (C) P-RBL1 (TMA 1–3), and (D) P-LARP6 (TMA 1–3). TMA 1: Nor = 5, tumor = 25; TMA 2: Nor = 5, tumor = 12; TMA 3: n = 5, tumor = 11. *p < 0.05, **p < 0.01, ***p < 0.001; values compared using Student’s t-test with Welch’s correction.